Pub. Date : 2011 Jun
PMID : 21704401
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, recently it was suggested that lactate produced in hypoxic tumor areas may be taken up by the monocarboxylate transporter MCT1 and oxidized in well-oxygenated tumor parts. | Lactic Acid | modifier of curly tail 1 | Mus musculus |
| 2 | Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor alpha-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor oxygenation and indirectly kills radio-resistant hypoxic tumor cells from glucose starvation. | Lactic Acid | modifier of curly tail 1 | Mus musculus |
| 3 | Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor alpha-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor oxygenation and indirectly kills radio-resistant hypoxic tumor cells from glucose starvation. | Lactic Acid | modifier of curly tail 1 | Mus musculus |