Pub. Date : 1990 Oct 15
PMID : 2170380
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | There have been few studies in fibroblasts which characterize the pattern and relationship of phosphatidylinositol 4,5-bisphosphate (PIP2) and non-phosphoinositide hydrolysis elicited by VP. | Phosphatidylinositol 4,5-Diphosphate | arginine vasopressin | Rattus norvegicus |
| 2 | There have been few studies in fibroblasts which characterize the pattern and relationship of phosphatidylinositol 4,5-bisphosphate (PIP2) and non-phosphoinositide hydrolysis elicited by VP. | Phosphatidylinositol 4,5-Diphosphate | arginine vasopressin | Rattus norvegicus |
| 3 | Here we demonstrate that VP-induced PIP2 hydrolysis is closely accompanied by phosphatidylcholine (PC) degradation by phospholipase D. Cells prelabeled with [3H]arachidonic acid showed rapid formation and diminution of [3H]diacylglycerol (DG) (5-15s) when treated with VP; this was accompanied by a reduction in polyphosphoinositide radioactivity. | Phosphatidylinositol 4,5-Diphosphate | arginine vasopressin | Rattus norvegicus |
| 4 | Here we demonstrate that VP-induced PIP2 hydrolysis is closely accompanied by phosphatidylcholine (PC) degradation by phospholipase D. Cells prelabeled with [3H]arachidonic acid showed rapid formation and diminution of [3H]diacylglycerol (DG) (5-15s) when treated with VP; this was accompanied by a reduction in polyphosphoinositide radioactivity. | Phosphatidylinositol 4,5-Diphosphate | arginine vasopressin | Rattus norvegicus |
| 5 | These data demonstrate that VP elicits the coordinated hydrolysis of PIP2 by phospholipase C and PC hydrolysis by phospholipase D. This event results in the prolonged generation of PA and biphasic formation of DG. | Phosphatidylinositol 4,5-Diphosphate | arginine vasopressin | Rattus norvegicus |