Title : A mechanism of D-(+)-sotalol effects on heart rate not related to beta-adrenoceptor antagonism.

Pub. Date : 1990 Aug

PMID : 2169833






2 Functional Relationships(s)
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1 We also studied the affinity of human lymphocyte beta 2-adrenoceptor for (+)-sotalol, (-)-sotalol, and (+/-)-propranolol. Propranolol adrenoceptor beta 2 Homo sapiens
2 The affinity of the human lymphocyte beta 2-adrenoceptor was approximately 60-fold greater for (-)-sotalol (Ki, 108 +/- 12 nM) than for (+)-sotalol (Ki, 6,410 +/- 1,020 nM), and approximately 20,000-fold greater for (+/-)-propranolol (Ki, 0.33 +/- 0.08 nM) than for (+)-sotalol. Propranolol adrenoceptor beta 2 Homo sapiens