Title : Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells.

Pub. Date : 2012 Jan 12

PMID : 21685938






1 Functional Relationships(s)
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1 Our results indicate that HA binding to CD44 promotes Nanog-Stat-3 (also tyrosine phosphorylated Stat-3) complex formation, nuclear translocation and transcriptional activation. Tyrosine Nanog homeobox Homo sapiens