Pub. Date : 2011 Jul 15
PMID : 21677136
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Recently, production of reactive oxygen species (ROS) has been suggested to act as a common event upstream of the NLRP3 inflammasome machinery. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Recently, production of reactive oxygen species (ROS) has been suggested to act as a common event upstream of the NLRP3 inflammasome machinery. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Although we observe that NLRP3 inflammasome activation is unique among other known inflammasomes in its sensitivity to ROS inhibition, we have found that this phenomenon is attributable to the fact that NLRP3 strictly requires priming by a proinflammatory signal, a step that is blocked by ROS inhibitors. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | Although we observe that NLRP3 inflammasome activation is unique among other known inflammasomes in its sensitivity to ROS inhibition, we have found that this phenomenon is attributable to the fact that NLRP3 strictly requires priming by a proinflammatory signal, a step that is blocked by ROS inhibitors. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 6 | Although we observe that NLRP3 inflammasome activation is unique among other known inflammasomes in its sensitivity to ROS inhibition, we have found that this phenomenon is attributable to the fact that NLRP3 strictly requires priming by a proinflammatory signal, a step that is blocked by ROS inhibitors. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 7 | Although we observe that NLRP3 inflammasome activation is unique among other known inflammasomes in its sensitivity to ROS inhibition, we have found that this phenomenon is attributable to the fact that NLRP3 strictly requires priming by a proinflammatory signal, a step that is blocked by ROS inhibitors. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 8 | Although these data do not exclude a general role for ROS production in the process of NLRP3-triggered inflammation, they would put ROS upstream of NLRP3 induction, but not activation. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |