Pub. Date : 1978 Nov-Dec
PMID : 216760
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In some preparations vanadium was found to be the most potent inhibitor of Na+ + K+ATPase activity so far reported. | Vanadium | ATPase Na+/K+ transporting subunit beta 1 | Homo sapiens |
| 2 | Concentrations of vanadium causing 50 percent inhibition of Na+ + K+ATPase activity ranged from 6 x 10(-8) to 5 x 10(-7) M in microsomal fractions and from 2 x 10(-7) to 1 x 10(-6) M in tissue homogenates. | Vanadium | ATPase Na+/K+ transporting subunit beta 1 | Homo sapiens |
| 3 | Mg2+ ATPase, which contaminated the enzyme preparations to a variable degree, was 1,000-10,000 times more resistant to vanadium than was Na+ + K+ATPase. | Vanadium | ATPase Na+/K+ transporting subunit beta 1 | Homo sapiens |
| 4 | This could mean that vanadium inhibits the Na+ + K+ATPase at the site activated by Na+, and that ATP protects the enzyme either by binding vanadium or by competing for a mutual receptor on the enzyme. | Vanadium | ATPase Na+/K+ transporting subunit beta 1 | Homo sapiens |