Title : Emerging methodologies for the study of hypothalamic gonadotropin-releasing-hormone (GnRH) neurons.

Pub. Date : 2008 Nov

PMID : 21669816






2 Functional Relationships(s)
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1 We used dynamic current-clamping to understand how living GnRH somata process input from glutamate and GABA, two key neurotransmitters in the neuroendocrine hypothalamus. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Homo sapiens
2 Furthermore, application of simulated GABAergic synapses with a depolarized reversal potential have revealed two functional subpopulations of GnRH neurons: one population in which GABA chronically depolarizes membrane potential (without inducing action potentials) and a second population in which GABAergic excitation results in slow spiking. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Homo sapiens