Title : JNK Inhibition Protects Dopamine Neurons and Provides Behavioral Improvement in a Rat 6-hydroxydopamine Model of Parkinson's Disease.

Pub. Date : 2011 Apr 20

PMID : 21666838






1 Functional Relationships(s)
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1 To fill this void we developed an aminopyrimidine JNK inhibitor (SR-3306) that reduced the loss of dopaminergic cell bodies in the SNpc and their terminals in the striatum produced by unilateral injection of 6-hydroxydopamine (6-OHDA) into the nigrostriatal pathway. 2-aminopyrimidine mitogen-activated protein kinase 8 Rattus norvegicus