Title : A critical step for JNK activation: isomerization by the prolyl isomerase Pin1.

Pub. Date : 2012 Jan

PMID : 21660049






1 Functional Relationships(s)
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1 These results provide novel insights that, following stress-induced phosphorylation of Thr in the Thr-Pro motif of JNK1, JNK1 associates with Pin1 and undergoes conformational changes to promote the binding of JNK1 to its substrates, resulting in cellular responses from extracellular signals. Proline peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens