Pub. Date : 2011 Aug
PMID : 21655990
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Messenger RNA expression was significantly downregulated by metformin for PDE3B (phosphodiesterase 3B, cGMP-inhibited; a critical regulator of cAMP levels that affect activation of AMP-activated protein kinase, AMPK), confirmed by immunohistochemistry, SSR3, TP53 and CCDC14. | Metformin | tumor protein p53 | Homo sapiens |
| 2 | Gene set analysis additionally revealed that p53, BRCA1 and cell cycle pathways also had reduced expression following metformin. | Metformin | tumor protein p53 | Homo sapiens |