Title : A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome.

Pub. Date : 2011 Sep 1

PMID : 21653638






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Expanded polyglutamine (polyQ) tract in the human TATA-box-binding protein (hTBP) causes the neurodegenerative disease spinocerebellar ataxia 17 (SCA17). polyglutamine ataxin 7 Homo sapiens
2 Expanded polyglutamine (polyQ) tract in the human TATA-box-binding protein (hTBP) causes the neurodegenerative disease spinocerebellar ataxia 17 (SCA17). polyglutamine ataxin 7 Homo sapiens
3 To investigate the pathological effects of polyQ expansion, we established a SCA17 model in Drosophila. polyglutamine ataxin 7 Homo sapiens