Pub. Date : 1990 Jun
PMID : 2163473
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential modulation of ACTH-stimulated cortisol and androstenedione secretion by insulin. | Androstenedione | insulin | Bos taurus |
| 2 | In contrast, insulin exhibited biphasic effects on the secretion of androstenedione by cells maintained in the presence of ACTH for 24 h; an effect that was most dramatic in the presence of a maximal concentration of ACTH. | Androstenedione | insulin | Bos taurus |
| 3 | At an insulin concentration of 0.1 ng/ml, androstenedione secretion by cells maintained in the presence of 10 nM ACTH was increased approximately 2.5-fold. | Androstenedione | insulin | Bos taurus |
| 4 | At higher concentrations of insulin, ACTH-stimulated androstenedione secretion was inhibited to an extent comparable to that in cortisol secretion. | Androstenedione | insulin | Bos taurus |
| 5 | The effects of insulin on ACTH-stimulated cortisol and androstenedione secretion could not be accounted for by changes in steroid degradation or a loss in 11 beta-hydroxylase activity. | Androstenedione | insulin | Bos taurus |