Title : Cyclopamine reverts acquired chemoresistance and down-regulates cancer stem cell markers in pancreatic cancer cell lines.

Pub. Date : 2011

PMID : 21630164






1 Functional Relationships(s)
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1 RESULTS: CD44, CD133 and the expression level of HH members, including Shh, SMO, Gli-1, were found to be highly expressed in gemcitabine-resistant cells, which were significantly down-regulated by cyclopamine treatment. cyclopamine smoothened, frizzled class receptor Homo sapiens