Title : Forced expression of HLA-DM at the surface of dendritic cells increases loading of synthetic peptides on MHC class II molecules and modulates T cell responses.

Pub. Date : 2011 Jul 1

PMID : 21622867






3 Functional Relationships(s)
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1 In an effort to increase the loading of therapeutic synthetic peptides on MHC II molecules, we used a mutant of HLA-DM (DMY) devoid of its lysosomal sorting motif and that accumulates at the cell surface. 5,6-dehydrokawain histocompatibility-2, MHC Mus musculus
2 Finally, we found that DMY(-) and DMY(+) mouse APCs differentially stimulated T cell hybridomas sensitive to the fine conformation of peptide-MHC II complexes. 5,6-dehydrokawain histocompatibility-2, MHC Mus musculus
3 Finally, we found that DMY(-) and DMY(+) mouse APCs differentially stimulated T cell hybridomas sensitive to the fine conformation of peptide-MHC II complexes. 5,6-dehydrokawain histocompatibility-2, MHC Mus musculus