Pub. Date : 2011 Aug
PMID : 21620734
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Heat shock protein 90 mediates anti-apoptotic effect of diazoxide by preventing the cleavage of Bid in hypothermic preservation rat hearts. | Diazoxide | BH3 interacting domain death agonist | Rattus norvegicus |
| 2 | The cleavage of Bid increased after 9 hours of hypothermic preservation, which was inhibited by Celsior solution supplemented with diazoxide. | Diazoxide | BH3 interacting domain death agonist | Rattus norvegicus |
| 3 | The Hsp90 inhibitor 17-allylamino-17-demethoxy-geldanamycin inhibited the diazoxide-induced decrease in cleavage of Bid, improvement of cardiac function, and decrease of apoptosis. | Diazoxide | BH3 interacting domain death agonist | Rattus norvegicus |
| 4 | CONCLUSION: Hsp90 might mediate diazoxide-induced cardioprotection against apoptosis in hypothermic preservation heart by preventing the cleavage of Bid. | Diazoxide | BH3 interacting domain death agonist | Rattus norvegicus |