Pub. Date : 2011 Jul 15
PMID : 21606497
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine inhibits the release of TNF-alpha from macrophage through activation of STAT3. | Nicotine | tumor necrosis factor | Homo sapiens |
| 2 | Nicotine induced activation of STAT3 enhanced STAT3 binding to the TTP promoter, increased TTP promoter activity, and increased TTP expression resulting in the suppression of LPS-stimulated TNF-alpha production. | Nicotine | tumor necrosis factor | Homo sapiens |
| 3 | Overexpression of a dominant negative mutant of STAT3 (R382W) or down-regulation of STAT3 by siRNA abolished nicotine-induced TTP expression and suppression of LPS-stimulated TNF-alpha production. | Nicotine | tumor necrosis factor | Homo sapiens |
| 4 | Nicotine enhanced the decay of TNF-alpha mRNA and decreased luciferase expression of a TNF-alpha 3"-UTR reporter plasmid in U937 cells. | Nicotine | tumor necrosis factor | Homo sapiens |
| 5 | Nicotine enhanced the decay of TNF-alpha mRNA and decreased luciferase expression of a TNF-alpha 3"-UTR reporter plasmid in U937 cells. | Nicotine | tumor necrosis factor | Homo sapiens |