Pub. Date : 2011 Jul 1
PMID : 21606250
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The immunosuppressive calcineurin inhibitors (CNIs) cyclosporine A (CsA) and tacrolimus are widely used in transplant organ recipients, but in the kidney allograft, they may cause tubulointerstitial as well as mesangial fibrosis, with TGF-beta believed to be a central inductor. | Tacrolimus | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | In this study, we report that the cold-shock protein Y-box binding protein-1 (YB-1) is a TGF-beta independent downstream effector in CsA- as well as in tacrolimus- but not in rapamycin-mediated activation of rat mesangial cells (rMCs). | Tacrolimus | transforming growth factor, beta 1 | Rattus norvegicus |