Title : Perifosine-induced inhibition of Akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance in neuroblastoma in vivo.

Pub. Date : 2011 Dec 1

PMID : 21590687






3 Functional Relationships(s)
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1 RESULTS: In vitro BDNF treatment induced Akt phosphorylation and rescued cells from etoposide-induced cell death in cells with high TrkB expression, but not in cells with low TrkB expression. Etoposide brain derived neurotrophic factor Mus musculus
2 Pretreatment of high TrkB-expressing TB3 cells with perifosine blocked BDNF/TrkB-induced Akt phosphorylation and inhibited BDNF"s protection of TB3 cells from etoposide treatment. Etoposide brain derived neurotrophic factor Mus musculus
3 Pretreatment of high TrkB-expressing TB3 cells with perifosine blocked BDNF/TrkB-induced Akt phosphorylation and inhibited BDNF"s protection of TB3 cells from etoposide treatment. Etoposide brain derived neurotrophic factor Mus musculus