Pub. Date : 1990 May 15
PMID : 2159035
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We investigated, in vitro and in vivo, the cyclosporin A (CsA) regulation of LPS-induced TNF gene expression and subsequent pathophysiologic changes. | Cyclosporine | tumor necrosis factor | Mus musculus |
| 2 | In vitro dose-response kinetics data showed that CsA inhibited TNF bioactivity in the supernatant without delaying its production, whereas Northern blot and in situ hybridization analysis demonstrated that CsA did not inhibit TNF mRNA expression. | Cyclosporine | tumor necrosis factor | Mus musculus |
| 3 | CsA demonstrated suppression of local levels (ascites) of TNF as measured by either bioactivity or an anti-murine TNF ELISA. | Cyclosporine | tumor necrosis factor | Mus musculus |
| 4 | CsA demonstrated suppression of local levels (ascites) of TNF as measured by either bioactivity or an anti-murine TNF ELISA. | Cyclosporine | tumor necrosis factor | Mus musculus |
| 5 | In vivo kinetics studies were performed to show that CsA blocked both local (ascites) and systemic (plasma) LPS-induced TNF production without delaying these effects. | Cyclosporine | tumor necrosis factor | Mus musculus |
| 6 | These observations are helpful in understanding the role of the macrophage in CsA immunosuppression, particularly with regard to the ability of CsA to block LPS-induced TNF secretion. | Cyclosporine | tumor necrosis factor | Mus musculus |