Pub. Date : 2011 Sep
PMID : 21586312
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The bile acid binding to AKR1B14 mainly accelerates the NADP(+) dissociation, the rate-limited step of the enzyme reaction. | NADP | aldo-keto reductase family 1, member B7 | Rattus norvegicus |
| 2 | The results, together with the docking of the bile acid in the recently determined crystal structure of AKR1B14, identify the bile acid-binding site of which His269 plays a key role in significant activation through its electrostatic interaction with the carboxyl group of bile acid, facilitating the release of NADP(+). | NADP | aldo-keto reductase family 1, member B7 | Rattus norvegicus |