Pub. Date : 2011 May 5
PMID : 21573174
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway. | Glucose | tumor protein p53 | Homo sapiens |
| 2 | BACKGROUND: Glucose restriction in cells increases the AMP/ATP ratio (energetic stress), which activates the AMPK/p53 pathway. | Glucose | tumor protein p53 | Homo sapiens |
| 3 | METHODOLOGY/PRINCIPAL FINDINGS: We found that glucose restriction or treatment of human diploid fibroblasts (HDFs) with the activators of the AMPK/p53 pathway induced the expression of IFI16 protein. | Glucose | tumor protein p53 | Homo sapiens |
| 4 | Importantly, the knockdown of the IFI16 expression in HDFs inhibited the activation of the ATM/AMPK/p53 pathway in response to glucose restriction and also increased the survival of HDFs. | Glucose | tumor protein p53 | Homo sapiens |