Title : DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs.

Pub. Date : 2011 May 10

PMID : 21572997






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here we show that inhibition of DNA methyltransferases (DNMTs) with 5-azacytidine (5-AzaC) or with specific small interfering RNA (siRNA) against DNMT1 and 3b induced the cellular senescence of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs) and increased p16(INK4A) and p21(CIP1/WAF1) expression. Azacitidine cyclin dependent kinase inhibitor 2A Homo sapiens
2 Here we show that inhibition of DNA methyltransferases (DNMTs) with 5-azacytidine (5-AzaC) or with specific small interfering RNA (siRNA) against DNMT1 and 3b induced the cellular senescence of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs) and increased p16(INK4A) and p21(CIP1/WAF1) expression. Azacitidine cyclin dependent kinase inhibitor 2A Homo sapiens