Pub. Date : 2011 Apr 29
PMID : 21572519
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer. | Tyrosine | annexin A2 | Homo sapiens |
| 2 | Furthermore, cell-surface localization of ANXA2 is tyrosine 23 phosphorylation-dependent; and tyrosine 23 phosphorylation is required for PDA invasion. | Tyrosine | annexin A2 | Homo sapiens |
| 3 | We demonstrated that tyrosine 23 phosphorylation resulting in surface expression of ANXA2 is required for TGFbeta-induced, Rho-mediated epithelial-mesenchymal transition (EMT), linking the cellular function of ANXA2 which was previously shown to be associated with small GTPase-regulated cytoskeletal rearrangements, to the EMT process in PDA. | Tyrosine | annexin A2 | Homo sapiens |
| 4 | We demonstrated that tyrosine 23 phosphorylation resulting in surface expression of ANXA2 is required for TGFbeta-induced, Rho-mediated epithelial-mesenchymal transition (EMT), linking the cellular function of ANXA2 which was previously shown to be associated with small GTPase-regulated cytoskeletal rearrangements, to the EMT process in PDA. | Tyrosine | annexin A2 | Homo sapiens |