Pub. Date : 2011 Jul 1
PMID : 21569840
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our data also showed that the basal level of AhR and the BaP-induced level of Nrf2 were significantly higher in hCatTg MAECs than in wild-type cells. | Benzo(a)pyrene | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 2 | Knockdown of AhR by RNA interference diminished BaP-induced expression of Nrf2 and NQO1. | Benzo(a)pyrene | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 3 | Knockdown of Nrf2 significantly decreased NQO1 mRNA and protein levels in cells with or without BaP treatment. | Benzo(a)pyrene | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 4 | These results suggest that catalase overexpression upregulates BaP-induced NQO1 expression by enhancing the Sp1-AhR-Nrf2 signaling cascade. | Benzo(a)pyrene | nuclear factor, erythroid derived 2, like 2 | Mus musculus |