Title : Agmatine in the hypothalamic paraventricular nucleus stimulates feeding in rats: involvement of neuropeptide Y.

Pub. Date : 2011 Sep

PMID : 21564088






5 Functional Relationships(s)
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1 Agmatine in the hypothalamic paraventricular nucleus stimulates feeding in rats: involvement of neuropeptide Y. Agmatine neuropeptide Y Rattus norvegicus
2 Similarly, NPY and [Leu31, Pro34]-NPY potentiated the agmatine-induced hyperphagia, whereas BIBP3226 inhibited it. Agmatine neuropeptide Y Rattus norvegicus
3 Similarly, NPY and [Leu31, Pro34]-NPY potentiated the agmatine-induced hyperphagia, whereas BIBP3226 inhibited it. Agmatine neuropeptide Y Rattus norvegicus
4 Agmatine increased NPY immunoreactivity in the PVN fibres and in the cells of the hypothalamic arcuate nucleus (ARC) and this effect was prevented by pretreatment with yohimbine. Agmatine neuropeptide Y Rattus norvegicus
5 CONCLUSIONS AND IMPLICATIONS: The orexigenic effect of agmatine is coupled to increased NPY activity mediated by stimulation of alpha2-adrenoceptors within the PVN. Agmatine neuropeptide Y Rattus norvegicus