Title : Conservation of complex nuclear localization signals utilizing classical and non-classical nuclear import pathways in LANA homologs of KSHV and RFHV.

Pub. Date : 2011 Apr 29

PMID : 21559489






1 Functional Relationships(s)
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1 Our studies revealed that both LANA proteins contain an N-terminal arginine/glycine (RG)-rich domain spanning a conserved chromatin-binding motif, which binds directly to importin beta1 in a RanGTP-sensitive manner and serves as an NLS in the importin beta1-mediated non-classical nuclear import pathway. Glycine LANA Human gammaherpesvirus 8