Title : A deeply recessed active site in angiotensin-converting enzyme is indicated from the binding characteristics of biotin-spacer-inhibitor reagents.

Pub. Date : 1990 Feb 28

PMID : 2155615






2 Functional Relationships(s)
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1 Two biotinylated derivatives of the angiotensin-converting enzyme (ACE) inhibitor, lisinopril, were synthesized. Lisinopril angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus
2 These results indicate that the bound determinant of lisinopril must lie at least 11 A below the outer surface of the ACE molecule. Lisinopril angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus