Title : p53 promotes cellular survival in a context-dependent manner by directly inducing the expression of haeme-oxygenase-1.

Pub. Date : 2011 Nov 3

PMID : 21552291






1 Functional Relationships(s)
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1 Although p53 and its classical targets such as p21 and Mdm2 are activated by both H(2)O(2) and CDDP, we found that the expression of haeme-oxygenase-1 (HO-1)-an antioxidant and antiapoptotic protein-was directly induced only upon H(2)O(2) treatment in a p53-dependent manner. Cisplatin heme oxygenase 1 Homo sapiens