Title : HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements.

Pub. Date : 2011 Jul

PMID : 21543478






1 Functional Relationships(s)
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1 The interaction with AP-1 required for CD28 and CD8beta differed from the AP-1 interaction required for MHC-I downmodulation in that it was mediated through the dileucine motif within Nef (LL(164,165)AA) and did not require the tyrosine binding pocket of the AP-1 mu subunit. dileucine S100 calcium binding protein B Homo sapiens