Title : Host-based ribavirin resistance influences hepatitis C virus replication and treatment response.

Pub. Date : 2011 Jul

PMID : 21543469






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 When Huh7.5 cells were exposed to RBV, resistance developed through reduced RBV uptake via the ENT1 nucleoside transporter and antiviral efficacy was reduced. Ribavirin solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
2 When Huh7.5 cells were exposed to RBV, resistance developed through reduced RBV uptake via the ENT1 nucleoside transporter and antiviral efficacy was reduced. Ribavirin solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
3 The uptake defect in RBV-resistant cells was specific to RBV, since transport of another ENT1 substrate, cytidine, was unaffected. Ribavirin solute carrier family 29 member 1 (Augustine blood group) Homo sapiens