Title : Pre-emptive morphine treatment abolishes nerve injury-induced lysophospholipid synthesis in mass spectrometrical analysis.

Pub. Date : 2011 Jul

PMID : 21542849






3 Functional Relationships(s)
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1 The levels of 16:0-, 18:0- and 18:1-LPC in the spinal cord and dorsal root were maximally increased at 75 min after SCNI and then declined, as LPC is converted to LPA by autotaxin (ATX). lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus
2 The levels of 16:0-, 18:0- and 18:1-LPC in the spinal cord and dorsal root were maximally increased at 75 min after SCNI and then declined, as LPC is converted to LPA by autotaxin (ATX). lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus
3 In atx(+/-)-mice, on the other hand, these levels were similar to wild-type mice at 75 min, but maximal at 120 min, suggesting that this difference is partly due to the low conversion of LPC to LPA in atx(+/-)-mice. lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus