Title : Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase.

Pub. Date : 2011 May 26

PMID : 21542630






2 Functional Relationships(s)
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1 Dual target inhibitors against COX-2 and LTA(4)H were designed by adding functional groups from a marketed COX-2 inhibitor, Nimesulide, to an existing LTA(4)H inhibitor 1-(2-(4-phenoxyphenoxy) ethyl) pyrrolidine. nimesulide mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Dual target inhibitors against COX-2 and LTA(4)H were designed by adding functional groups from a marketed COX-2 inhibitor, Nimesulide, to an existing LTA(4)H inhibitor 1-(2-(4-phenoxyphenoxy) ethyl) pyrrolidine. nimesulide mitochondrially encoded cytochrome c oxidase II Homo sapiens