Title : Extracellular Na+, but not Na+/H+ exchange, is necessary for receptor-mediated arachidonate release in platelets.

Pub. Date : 1990 Jan 1

PMID : 2154180






2 Functional Relationships(s)
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1 Replacement with choline+, K+, N-methylglucamine+ (which abolished the thrombin-induced pHi rise) or Li+ (which allowed a normal thrombin-induced pHi rise) significantly decreased arachidonate release in response to all concentrations (threshold to supra-maximal) of thrombin and collagen. Arachidonic Acid coagulation factor II, thrombin Homo sapiens
2 Inhibition of thrombin-induced pHi rises was seen with 0.5-5 microM-5-NN-ethylisopropylamiloride (EIPA), but at these concentrations EIPA had little effect on thrombin-induced arachidonate release. Arachidonic Acid coagulation factor II, thrombin Homo sapiens