Title : Role of ANG II in eicosanoid production by isolated glomeruli from rats with bilateral ureteral obstruction.

Pub. Date : 1990 Jan

PMID : 2154128






4 Functional Relationships(s)
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1 The prostanoid production in response to addition of ANG II or AVP in vitro was blunted in glomeruli from BUO rats, but the response was restored to "normal" after blockade of ANG II synthesis in vivo in BUO rats. Prostaglandins angiotensinogen Rattus norvegicus
2 The prostanoid generation in response to addition of both ANG II and arachidonic acid in vitro compared with ANG II addition alone was not significantly stimulated in glomeruli from BUO rats. Prostaglandins angiotensinogen Rattus norvegicus
3 The results indicate that endogenous ANG II has an important role in the increased synthesis of prostanoids found in isolated glomeruli of rats with BUO and that the in vitro prostanoid production in response to ANG II and AVP can be restored to normal when the synthesis of ANG II is inhibited in vivo. Prostaglandins angiotensinogen Rattus norvegicus
4 The results indicate that endogenous ANG II has an important role in the increased synthesis of prostanoids found in isolated glomeruli of rats with BUO and that the in vitro prostanoid production in response to ANG II and AVP can be restored to normal when the synthesis of ANG II is inhibited in vivo. Prostaglandins angiotensinogen Rattus norvegicus