Title : Comparative analysis reveals selective recognition of glycans by the dendritic cell receptors DC-SIGN and Langerin.

Pub. Date : 2011 Sep

PMID : 21540232






3 Functional Relationships(s)
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1 In this side-by-side study DC-SIGN was found to preferentially bind internal mannose residues of high-mannose-type saccharides and the fucose-containing blood-type antigens H, A, B, Le(a), Le(b) Le(x), Le(y), sialyl-Le(a) as well as sulfatated derivatives of Le(a) and Le(x). Carbohydrates CD209 molecule Homo sapiens
2 The precise knowledge of carbohydrate specificity of DC-SIGN and Langerin receptors resulting from our study may aid the future design of microbicides that specifically affect the DC-SIGN/HIV-1 interaction while not compromising the protective function of Langerin. Carbohydrates CD209 molecule Homo sapiens
3 The precise knowledge of carbohydrate specificity of DC-SIGN and Langerin receptors resulting from our study may aid the future design of microbicides that specifically affect the DC-SIGN/HIV-1 interaction while not compromising the protective function of Langerin. Carbohydrates CD209 molecule Homo sapiens