Title : p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin.

Pub. Date : 2011 Apr 21

PMID : 21532991






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here we show that siRNA-mediated silencing of p53 is sufficient to completely abrogate hypersensitivity not only to Cisplatin but also to non-genotoxic inducers of p53 such as the Mdm2 antagonist Nutlin-3 and the proteasome inhibitor Bortezomib. Bortezomib tumor protein p53 Homo sapiens