Title : The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility.

Pub. Date : 2011 Jul

PMID : 21527500






1 Functional Relationships(s)
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1 cAMP accumulation in response to hCG stimulation in primary cultures of Leydig cells from Mek1(f/f);Mek2(-/-);iCre(+) mice is normal, but basal testosterone and testosterone syntheses provoked by addition of hCG or a cAMP analog, or by addition of substrates such as 22-hydroxycholesterol or pregnenolone, are barely detectable. Pregnenolone hypertrichosis 2 (generalised, congenital) Homo sapiens