Title : The purpose of the HIF-1/PHD feedback loop: to limit mTOR-induced HIF-1α.

Pub. Date : 2011 May 15

PMID : 21521942






1 Functional Relationships(s)
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1 The failure to limit mTOR-dependent induction of HIF-1 may contribute to age-related macular degeneration and diabetic retinopathy, suggesting rapamycin for prevention of these age-related diseases. Sirolimus hypoxia inducible factor 1 subunit alpha Homo sapiens