Pub. Date : 2011 Oct
PMID : 21512969
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Andrographolide inhibits PI3K/AKT-dependent NOX2 and iNOS expression protecting mice against hypoxia/ischemia-induced oxidative brain injury. | andrographolide | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | In BV-2 cells, OGD induced ROS and nitric oxide production by upregulating NOX2 and iNOS via the phosphatidylinositol-3-kinase (PI3K)/AKT-dependent NF- kappaB and HIF-1 alpha pathways, and these changes were suppressed by andrographolide and LY294002. | andrographolide | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Our results indicate that andrographolide reduces NOX2 and iNOS expression possibly by impairing PI3K/AKT-dependent NF- kappaB and HIF-1 alpha activation. | andrographolide | thymoma viral proto-oncogene 1 | Mus musculus |