Title : Modulation of extracellular matrix metabolism in rabbit articular chondrocytes and human rheumatoid synovial cells by the non-steroidal anti-inflammatory drug etodolac. II: Glycosaminoglycan synthesis.

Pub. Date : 1990 Nov

PMID : 2150741






4 Functional Relationships(s)
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1 When cells were incubated with Interleukin-1 (IL-1), Etodolac still exerted its inhibiting effect on GAG synthesis. Glycosaminoglycans interleukin 1 alpha Homo sapiens
2 When cells were incubated with Interleukin-1 (IL-1), Etodolac still exerted its inhibiting effect on GAG synthesis. Glycosaminoglycans interleukin 1 alpha Homo sapiens
3 IL-1 alone or in combination with Etodolac decreased the synthesis of GAGs suggesting that pretreatment with Etodolac cannot prevent the action of IL-1. Glycosaminoglycans interleukin 1 alpha Homo sapiens
4 In the same experiment, IL-1 alone caused a slight increase of GAG production that was not abolished by Etodolac treatment. Glycosaminoglycans interleukin 1 alpha Homo sapiens