Title : Histone deacetylases (HDACs) in XPC gene silencing and bladder cancer.

Pub. Date : 2011 Apr 20

PMID : 21507255






3 Functional Relationships(s)
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1 The results of our HDAC inhibition study revealed that the treatment of HTB4 and HTB9 bladder cancer cells with the HDAC inhibitor valproic acid (VPA) caused an increase in transcription of the XPC gene in these cells. Valproic Acid XPC complex subunit, DNA damage recognition and repair factor Homo sapiens
2 The results of our HDAC inhibition study revealed that the treatment of HTB4 and HTB9 bladder cancer cells with the HDAC inhibitor valproic acid (VPA) caused an increase in transcription of the XPC gene in these cells. Valproic Acid XPC complex subunit, DNA damage recognition and repair factor Homo sapiens
3 The results of our chromatin immunoprecipitation (ChIP) studies indicated that the VPA treatment caused increased binding of both CREB1 and Sp1 transcription factors at the promoter region of the XPC gene for both HTB4 and HTB9 cells. Valproic Acid XPC complex subunit, DNA damage recognition and repair factor Homo sapiens