Title : Bile acid receptor agonist GW4064 regulates PPARγ coactivator-1α expression through estrogen receptor-related receptor α.

Pub. Date : 2011 Jun

PMID : 21493670






5 Functional Relationships(s)
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1 Bile acid receptor agonist GW4064 regulates PPARgamma coactivator-1alpha expression through estrogen receptor-related receptor alpha. GW 4064 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus
2 In our effort to identify new regulators of PGC-1alpha expression, we found that GW4064, a widely used synthetic agonist for the nuclear bile acid receptor [farnesoid X receptor (FXR)] strongly enhances PGC-1alpha promoter reporter activity, mRNA, and protein expression. GW 4064 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus
3 In our effort to identify new regulators of PGC-1alpha expression, we found that GW4064, a widely used synthetic agonist for the nuclear bile acid receptor [farnesoid X receptor (FXR)] strongly enhances PGC-1alpha promoter reporter activity, mRNA, and protein expression. GW 4064 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus
4 Interestingly, FXR disruption alters GW4064 induction of PGC-1alpha mRNA in a tissue-dependent manner. GW 4064 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus
5 Using FXR-null [FXR knockout (FXRKO)] mice, we determined that GW4064 induction of PGC-1alpha expression is not affected in oxidative soleus muscles of FXRKO mice but is compromised in the FXRKO liver. GW 4064 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus