Pub. Date : 2011 Jun
PMID : 21493670
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bile acid receptor agonist GW4064 regulates PPARgamma coactivator-1alpha expression through estrogen receptor-related receptor alpha. | GW 4064 | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | Mus musculus |
| 2 | In our effort to identify new regulators of PGC-1alpha expression, we found that GW4064, a widely used synthetic agonist for the nuclear bile acid receptor [farnesoid X receptor (FXR)] strongly enhances PGC-1alpha promoter reporter activity, mRNA, and protein expression. | GW 4064 | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | Mus musculus |
| 3 | In our effort to identify new regulators of PGC-1alpha expression, we found that GW4064, a widely used synthetic agonist for the nuclear bile acid receptor [farnesoid X receptor (FXR)] strongly enhances PGC-1alpha promoter reporter activity, mRNA, and protein expression. | GW 4064 | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | Mus musculus |
| 4 | Interestingly, FXR disruption alters GW4064 induction of PGC-1alpha mRNA in a tissue-dependent manner. | GW 4064 | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | Mus musculus |
| 5 | Using FXR-null [FXR knockout (FXRKO)] mice, we determined that GW4064 induction of PGC-1alpha expression is not affected in oxidative soleus muscles of FXRKO mice but is compromised in the FXRKO liver. | GW 4064 | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | Mus musculus |