Title : Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-β and valproic acid.

Pub. Date : 2011 Jun 15

PMID : 21493591






1 Functional Relationships(s)
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1 Although DNA mismatch repair and O(6)-methylguanine (O(6)MeG)-DNA methyltransferase (MGMT) are key determinants of cellular resistance to these drugs, there is no correlation between these markers and the therapeutic response in melanoma, indicating as yet unknown mechanisms of drug resistance. O-(6)-methylguanine O-6-methylguanine-DNA methyltransferase Mus musculus