Title : Evaluation of 6β-hydroxycortisol, 6β-hydroxycortisone, and a combination of the two as endogenous probes for inhibition of CYP3A4 in vivo.

Pub. Date : 2011 Jun

PMID : 21490593






1 Functional Relationships(s)
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1 Given the significant decrease in CL(f) of 6beta-hydroxycortisone and 6beta-hydroxycortisol after 200-mg and 400-mg single doses of itraconazole, this endogenous probe can be used to detect moderate and potent CYP3A4 inhibition in vivo. Itraconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens