Title : Divergent C-H functionalizations directed by sulfonamide pharmacophores: late-stage diversification as a tool for drug discovery.

Pub. Date : 2011 May 11

PMID : 21488638






1 Functional Relationships(s)
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1 We then performed late-stage, site-selective diversification of a sulfonamide drug candidate containing multiple potentially reactive C-H bonds to synthesize directly novel celecoxib analogues as potential cyclooxygenase-II (COX-2)-specific inhibitors. Sulfonamides mitochondrially encoded cytochrome c oxidase II Homo sapiens