Pub. Date : 2011 May
PMID : 21484263
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synergic effects of beta-estradiol and erythromycin on hERG currents. | Erythromycin | ETS transcription factor ERG | Homo sapiens |
| 2 | With simultaneous application of 10 muM erythromycin, which is known to block hERG currents but not in low doses, the blocking effects of beta-estradiol on hERG currents were enhanced. | Erythromycin | ETS transcription factor ERG | Homo sapiens |
| 3 | With simultaneous application of 10 muM erythromycin, which is known to block hERG currents but not in low doses, the blocking effects of beta-estradiol on hERG currents were enhanced. | Erythromycin | ETS transcription factor ERG | Homo sapiens |
| 4 | Namely, hERG currents were inhibited maximally to 45.8% of control with an IC50 of 59 nM (P<0.02) by beta-estradiol with 10 muM erythromycin. | Erythromycin | ETS transcription factor ERG | Homo sapiens |
| 5 | We conclude here that a significant block of hERG currents by beta-estradiol may account for the sex-related differences in LQTS and the synergic effects of beta-estradiol and erythromycin indicate a higher risk of drug-induced TDP in women than men. | Erythromycin | ETS transcription factor ERG | Homo sapiens |