Pub. Date : 2011 Mar 29
PMID : 21479228
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats. | polyglutamine | ataxin 2 | Homo sapiens |
| 2 | Recently, intermediate length polyglutamine (polyQ) repeats of 27-33 in ATAXIN-2 (ATXN2), encoding the ATXN2 protein, were found to increase risk for ALS. | polyglutamine | ataxin 2 | Homo sapiens |
| 3 | Recently, intermediate length polyglutamine (polyQ) repeats of 27-33 in ATAXIN-2 (ATXN2), encoding the ATXN2 protein, were found to increase risk for ALS. | polyglutamine | ataxin 2 | Homo sapiens |
| 4 | Recently, intermediate length polyglutamine (polyQ) repeats of 27-33 in ATAXIN-2 (ATXN2), encoding the ATXN2 protein, were found to increase risk for ALS. | polyglutamine | ataxin 2 | Homo sapiens |
| 5 | Recently, intermediate length polyglutamine (polyQ) repeats of 27-33 in ATAXIN-2 (ATXN2), encoding the ATXN2 protein, were found to increase risk for ALS. | polyglutamine | ataxin 2 | Homo sapiens |
| 6 | Recently, intermediate length polyglutamine (polyQ) repeats of 27-33 in ATAXIN-2 (ATXN2), encoding the ATXN2 protein, were found to increase risk for ALS. | polyglutamine | ataxin 2 | Homo sapiens |
| 7 | Recently, intermediate length polyglutamine (polyQ) repeats of 27-33 in ATAXIN-2 (ATXN2), encoding the ATXN2 protein, were found to increase risk for ALS. | polyglutamine | ataxin 2 | Homo sapiens |
| 8 | In ATXN2, polyQ expansions of >= 34, which are pure CAG repeat expansions, cause spinocerebellar ataxia type 2. | polyglutamine | ataxin 2 | Homo sapiens |
| 9 | However, similar length expansions that are interrupted with other codons, can present atypically with parkinsonism, suggesting that configuration of the repeat sequence plays an important role in disease manifestation in ATXN2 polyQ expansion diseases. | polyglutamine | ataxin 2 | Homo sapiens |
| 10 | These results indicate that CAG repeat expansions in ATXN2 associated with ALS are uniformly interrupted repeats and that the nature of the repeat sequence and haplotype, as well as length of polyQ repeat, may play a role in the neurological effect conferred by expansions in ATXN2. | polyglutamine | ataxin 2 | Homo sapiens |