Pub. Date : 2011 Oct
PMID : 21474433
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Application of capsaicin (100 muM) attenuated vectorial anion transport, estimated as short-circuit currents (I(SC)), before and after stimulation by forskolin (10 muM) with concomitant reduction of cytosolic cyclic AMP (cAMP) levels. | Capsaicin | cathelicidin antimicrobial peptide | Homo sapiens |
| 2 | The capsaicin-induced inhibition of I(SC) was also observed in the response to 8-bromo-cAMP (1 mM, a cell-permeable cAMP analog) and 3-isobutyl-1-methylxanthine (1 mM, an inhibitor of phosphodiesterases). | Capsaicin | cathelicidin antimicrobial peptide | Homo sapiens |
| 3 | The capsaicin-induced inhibition of I(SC) was also observed in the response to 8-bromo-cAMP (1 mM, a cell-permeable cAMP analog) and 3-isobutyl-1-methylxanthine (1 mM, an inhibitor of phosphodiesterases). | Capsaicin | cathelicidin antimicrobial peptide | Homo sapiens |
| 4 | The capsaicin-induced inhibition of I(SC) was attributed to suppression of bumetanide (an inhibitor of the basolateral Na(+)-K(+)-2 Cl(-) cotransporter 1)- and 4,4"-dinitrostilbene-2,2"-disulfonic acid (an inhibitor of basolateral HCO(3)(-)-dependent anion transporters)-sensitive components, which reflect anion uptake via basolateral cAMP-dependent anion transporters. | Capsaicin | cathelicidin antimicrobial peptide | Homo sapiens |
| 5 | In contrast, capsaicin potentiated apical Cl(-) conductance, which reflects conductivity through the cystic fibrosis transmembrane conductance regulator, a cAMP-regulated Cl(-) channel. | Capsaicin | cathelicidin antimicrobial peptide | Homo sapiens |
| 6 | Collectively, capsaicinoids inhibit cAMP-mediated anion transport through down-regulation of basolateral anion uptake, paradoxically accompanied by up-regulation of apical cystic fibrosis transmembrane conductance regulator-mediated anion conductance. | Capsaicin | cathelicidin antimicrobial peptide | Homo sapiens |