Pub. Date : 2011 Jun
PMID : 21474332
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We analyzed the role of capsaicin in the tumor necrosis factor (TNF)-alpha secretion by PC-3 cells which was increased at shorter times than IL-6 production. | Capsaicin | tumor necrosis factor | Homo sapiens |
| 2 | Furthermore, incubation of PC-3 cells with an anti-TNF-alpha antibody blocked the capsaicin-induced IL-6 secretion. | Capsaicin | tumor necrosis factor | Homo sapiens |
| 3 | These results raise the possibility that capsaicin-mediated IL-6 increase in prostate cancer PC-3 cells is regulated at least in part by TNF-alpha secretion and signaling pathway involving Akt, ERK and PKC-alpha activation. | Capsaicin | tumor necrosis factor | Homo sapiens |