Title : Tanshinone IIA may inhibit the growth of small cell lung cancer H146 cells by up-regulating the Bax/Bcl-2 ratio and decreasing mitochondrial membrane potential.

Pub. Date : 2010 Jul-Aug

PMID : 21472292






1 Functional Relationships(s)
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1 The protein expression of GADD153 and Caspase-3 was increased, but the proto-oncogene bcl-2 was notably decreased in H146 cells treated with Tan-IIA (5 microg/ml) for 24 h. FACS showed that Tan-IIA may increase the production of ROS and Ca2+, but decreases MMP. Reactive Oxygen Species DNA damage inducible transcript 3 Homo sapiens